The other day I was at my neighbors house and we were shooting together, he has a single cam bow and I have a dual cam bow. SO! The question is, are all bows compatible with a single cam setup? I dont see why not. The single cam seemed to be a bit smoother than the dual cam. I am shooting a PSE Nova.
You can, but the limb deflection (to create appropriate draw weight) may/may not be the same. You also will need to come up with a custom cable/string length.
Basically it's more of a PITA than it's worth. You're better off just getting another bow of the type you want.