This, 2014 I shot a big bodied heavy mature deer. I hit him in the shoulder because my KE was high with a 450 grain arrow a Rage Titanium went thru both shoulder blades. Not sure the result would have been the same if I was pulling back 60 or less pounds.
I actually starting thinking about getting a new bow with a high ibo and lowering the draw weight to 60lbs. Every time I drew back on a deer I didn't have trouble at all but when I practice I want to be able to shoot for a while. I normally can't shoot more than 10 groups before I start to feel fatigued and my groups get bigger. I know someone is going to say it's the first shot that counts and yes you would be correct but I like to shoot my bow a lot.
My new bow is only 60# actually max out at 62#. I went to lower weight from my 70# bow. I never had any problems from the stand pulling the 70# bow back even on the coldest mornings. But I did notice that when I was just target shooting I could feel pain in my shoulder (old rotator cuff injury I believe) And I do a lot more target shooting than pulling back on a deer.
I pull 45 pounds, and I've shot 4 bucks in the last 2 years with that. I don't need anymore speed than that. I wouldn't look towards the full throttle simply because of the 5" brace height
Speed bows tend to have a harsher draw cycle. I dropped down from 65 to 60 and know plenty of guys shooting 45-50 range. 60-70lbs bows got it done 15 years ago, 40-50 bows of today will put out the same energy of those bows if not more. I can shoot all day and under the worst conditions after sitting for hours ,bundled up so that's what I shoot. Some will tell you that you lose the option of expanding heads( they may be right, I don't shoot them) but with heads like montecs,exodus and others who cares.