Schwacker actually makes a low poundage model. I'm considering these if I can't use my Rage heads with my rig.
All 3 of my deer were shot with swhacker and my bow was 60 lbs at the time and I didn't have any problems. They leave very nice blood trails.
I've shot schwackers the last several years and the standard 100gr that is 1 4/3 does very well even with lower KE. Schwacker says 50lbs KE needed for that broadhead. At 400gr you would need to be doing around 240fps which is likely unless you shoot an older bow with low IBO.
It'll be more than enough! I shoot 70 and its devastating on deer! just don't be punching shoulders all the time.